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Ciproxifan
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ciproxifan图片
CAS NO:184025-18-1
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
5mg询价
10mg询价
50mg询价

Ciproxifan (FUB 359) 是一种有效的、选择性的、具有口服生物利用度和竞争性的组胺 H3 受体拮抗剂，IC50 为 9.2 nM。
Cas No.184025-18-1
别名FUB-359
化学名cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
Canonical SMILESC1CC1C(=O)C2=CC=C(C=C2)OCCCC3=CN=CN3
分子式C16H18N2O2
分子量270.33
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ciproxifan is a novel and potent antagonist of histamine H3-receptor with a IC50 value of 9.2±1.8nM [1].

Ciproxifan has shown the in-vitro antagonistic action to H3-receptor with a IC50 value of 9.2±1.8nM. In addition, Ciproxifan has been reported to competitively antagonize the (R) α-MeHA induced relaxation of electrically stimulated guinea pig ileum longitudinal muscle. Besides, Ciproxifan has been revealed to have the effect on [125I]iodoproxyfan binding with a Ki value of 0.7±0.2 nM. Apart from these, Ciproxifan has been found to be a selective antagonist with pKi values of 9.3, 4.9, 4.6, 5.5, 5.4, 4.9,<5.0, 4.8,<5.5 and<5.7 for H3, H2, H1, muscarinic M3, adrenergic α1D, β1, serotonin 5-HT1B, 5-HT2A, 5-HT3 and 5-HT4, respectively [1].

References:
[1] Ligneau X1, Lin J, Vanni-Mercier G, Jouvet M, Muir JL, Ganellin CR, Stark H, Elz S, Schunack W, Schwartz J. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther. 1998 Nov; 287(2):658-66.

 
 
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