2614W94 是一种选择性 MAO-A 抑制剂，IC50 为 5 nM，Ki 为 1.6 nM。
产品描述
2614W94 is a selective inhibitor of MAO-A with IC50 of 5 nM and Ki of 1.6 nM.
体外活性
2614W94 (30 nM) shows no inhibition of MAO-B[1].
体内活性
In rats, 2614W94 (5 mg/kg, p.o.) selectively inhibits MAO-A in brains and livers and elevates neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a redcution of their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) dose-dependently potentiates 5-hydroxytryptophan-induced head twitches with an extrapolated ED50 of 1.1 mg/kg[1].
Cas No.
205187-35-5
分子式
C15H11F3O4S
分子量
344.31
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
