PPTN 是一种有效，高亲和力，竞争性和高选择性的 P2Y14 受体拮抗剂，KB 为 434 pM。PPTN 对 P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12 或 P2Y13 受体无激动剂或拮抗剂作用。具有抗炎和免疫活性。
产品描述
PPTN is a high-affinity, competitive and highly selective antagonist of P2Y14 receptor(KB value of 434 pM), with anti-inflammatory and immune activity.
体外活性
PPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM[1].
Cas No.
1160271-30-6
分子式
C29H24F3NO2
分子量
475.5
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
