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Zenarestat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Zenarestat图片
CAS NO:112733-06-9
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Zenarestat 是一种有效的、具有口服活性的醛糖还原酶 (aldose reductase) 抑制剂。Zenarestat 改善 Zucker 糖尿病脂肪大鼠的糖尿病周围神经病变。
Cas No.112733-06-9
别名折那司他
分子式C17H11BrClFN2O4
分子量441.64
溶解度DMSO : 100 mg/mL (226.43 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats[1].

Zenarestat (3.2, 32 mg/kg; p.o.; daily for 8 weeks) inhibits nerve sorbitol accumulation in a dose-dependent manner[1].

[1]. Shimoshige Y, et al. The effects of zenarestat, an aldose reductase inhibitor, on peripheral neuropathy in Zucker diabetic fatty rats. Metabolism. 2000;49(11):1395-1399.

 
 
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