Bis-PEG9-NHS ester

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Bis-PEG9-NHS ester

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1008402-79-6

包装与价格：

包装	价格(元)
25mg	询价
50mg	询价
100mg	询价

Bis-PEG9-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。Bis-PEG9-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG9-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

Cas No.	1008402-79-6
别名	双取代丙烯酸琥珀酰亚胺酯-二十四聚乙二醇
分子式	C30H48N2O17
分子量	708.71
溶解度	DMSO : 100 mg/mL (141.10 mM; Need ultrasonic)
储存条件	-20°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. [1]. Targeting m2-like tumor-associated macrophages by using melittin-based pro-apoptotic peptide. WO2019212324A1