2-(2-呋喃基)-7-[3-(4-甲氧苯基)丙基]-7H-吡唑并[4,3-E][1,2,4]三唑并[1,5-C]嘧啶-5-胺
SCH 442416
SCH442416 是选择性和可透过血脑屏障的腺苷A2A受体拮抗剂，对人和大鼠 A2AR 的Ki值分别为 0.048 和 0.5 nM，可用于在大鼠和灵长类动物大脑中对腺苷 A2A受体成像。
产品描述
SCH-442416 is an selective antagonist of adenosine A2A receptor. SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).
体外活性
The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions[1].
Cas No.
316173-57-6
分子式
C20H19N7O2
分子量
389.41
别名
2-(2-呋喃基)-7-[3-(4-甲氧苯基)丙基]-7H-吡唑并[4,3-E][1,2,4]三唑并[1,5-C]嘧啶-5-胺;SCH 442416
储存和溶解度
DMSO:60 mg/ml (154.08 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
