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PROTAC(H-PGDS)-7
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PROTAC(H-PGDS)-7图片
包装与价格：
包装价格(元)
500 µg询价
1mg询价

PROTAC(H-PGDS)-7 是一种造血前列腺素 D 合酶 (H-PGDS) PROTAC 降解剂，DC50 为 17.3 pM。
Canonical SMILESO=C(N1CCN(C2=C(C(N(C3C(NC(CC3)=O)=O)C4=O)=O)C4=CC=C2)CC1)C(CC5)CCN5C6=CC=C(NC(C7=CN=C(OC8=CC=CC=C8)N=C7)=O)C=C6
分子式C40H38N8O7
分子量742.8
溶解度DMSO: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PROTAC(H-PGDS)-7 is a proteolysis-targeting chimera (PROTAC) comprised of the hematopoietic prostaglandin D synthase (H-PGDS) inhibitor TFC-007 and the cereblon inhibitor pomalidomide .1It induces degradation of H-PGDS in KU812 cells with a 50% degradation concentration (DC50) value of 17.3 pM, as well as decreases the production of prostaglandin D2(PGD2) in the same cells.

1.Yokoo, H., Shibata, N., Endo, A., et al.Discovery of a highly potent and selective degrader targeting hematopoietic prostaglandin D synthase via in silico designJ. Med. Chem.64(21)15868-15882(2021)

 
 
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