ICA-105574 是HERG通道激活剂。它通过消除 HERG 通道的失活从而增强HERG 通道活性。它可以把电流幅度急剧增加到原来的 10 倍以上，其EC50值为 0.5 +/- 0.1 μM，Hill 斜率 (n(H)) 为 3.3 +/- 0.2。
产品描述
ICA-105574 is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel.
Cas No.
316146-57-3
分子式
C19H14N2O4
分子量
334.331
别名
3-nitro-N-[4-phenoxyphenyl]-benzamide;ICA
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
