L-Homopropargylglycine hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

942518-19-6

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
25mg	询价

L-Homopropargylglycine hydrochloride 是一种 PROTAC linker，属于 alkyl chain 类，可用于合成 PROTAC 分子。L-Homopropargylglycine hydrochloride 是蛋氨酸的氨基酸类似物，含有炔烃部分，可与含 Alexa Fluor 的叠氮化物发生经典的点击化学反应。

Cas No.	942518-19-6
别名	L-高炔丙基甘氨酸盐酸盐
分子式	C₆H₁₀ClNO₂
分子量	163.6
溶解度	DMSO : 125 mg/mL (764.06 mM; Need ultrasonic), ≤10mg/ml in PBS(pH7.2)
储存条件	Store at -20°C, away from moisture
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562. [2]. Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2(3):100616. Published 2021 Jun 17.