TCS-Pim-1-4a 是一种泛-Pim激酶抑制剂，可通过激活AMPK来阻断mTORC1的活性。它可杀死多种髓样和淋巴样细胞系，IC50值为 0.8 μM 至 40 μM。

TCS-PIM-1-4a, a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).

One hour inhibitor treatment (0.5 μM) of HEK-293T cultures at the end of a 4 hour 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 μM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 μM with respective inhibitor).

327033-36-3

C11H6F3NO2S

273.23

SMI-4a;5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years