MS645 是一种含溴结构域蛋白 4 (BRD4) 的抑制剂，对 BRD4-BD1/BD2 的 Ki 值为 18.4 nM。
产品描述
MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.
体外活性
MS645 blocks the proliferation of triple-negative breast cancer (TNBC) cells. MS645 down-regulates proinflammatory cytokines and genes for cell-cycle control and DNA damage repair that are largely unaffected by monovalent BRD inhibition[1].
Cas No.
2250091-96-2
分子式
C48H54Cl2N10O2S2
分子量
938.04
储存和溶解度
DMSO:180 mg/mL (191.9 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
