PF-9363 是一种有效且高选择性的 KAT6A/KAT6B 抑制剂，可用于癌症研究。
产品描述
PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
体外活性
PF-9363 (0~1 μM; 1 day) down-regulates the expression of H3K23Ac biomarker in ZR75-1, T47D and MCF7 cells[1]. PF-9363 downregulates a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. The IC50 values of PF-9363 for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1].
体内活性
PF-9363 exihibits strong anti-tumor activity in patient-derived xenograft models[1].
Cas No.
2569009-58-9
分子式
C20H20N4O6S
分子量
444.46
别名
CTX-3648
储存和溶解度
DMSO:55 mg/ml (123.75 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
