NAMPT-IN-5 是烟酰胺磷酸核糖基转移酶抑制剂。它可抑制 A2780 和 COR-L23 细胞，IC50值分别为 0.7 nM 和 3.9 nM。它还抑制 CYP3A4 活性。
产品描述
Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .
体外活性
Nampt-IN-5 shows a good ADME data: mouse microsomal clearance, CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6.Nampt-IN-5 has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively in CellTiterGlo (CTG) assays[1].
Cas No.
2380013-17-0
分子式
C25H25N5O2
分子量
427.5
储存和溶解度
DMSO:48mg/ml(112.28mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
