1,2,3,6-Tetragalloylglucose 是UDP-葡萄糖醛酸转移酶 1 家族成员,是多肽A1 的抑制剂(Ki:1.68 μM)。
产品描述
1,2,3,6-Tetragalloylglucose has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransferase 1 A1 (UGT1A1, Ki = 1.68 μM).
体外活性
Two phenolics, 1,2,6-trigalloylglucose (1) and 1,2,3,6-Tetragalloylglucose (2), isolated from the stem-bark of Juglans mandshurica were evaluated for their antioxidative activities. The results showed that compounds 1 and 1,2,3,6-Tetragalloylglucose exhibited strong scavenging activities against 1,1'-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzenthiazoline-6-sulphonic) acid (ABTS(*+)), and superoxide radicals (O(2)(*-)), and also had a significant inhibitory effect on lipid peroxidation and low-density lipoprotein (LDL) oxidation[1]
Cas No.
79886-50-3
分子式
C34H28O22
分子量
788.57
别名
1,2,3,6-Tetra-O-galloyl-β-D-glucose;TeGG;1,2,3,6-四-O-没食子酰-Β-D-葡萄糖
储存和溶解度
DMSO:91 mg/mL (115.40 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years