AZD-0284 是核受体 (RORγ) 的选择性反向激动剂。它对呼吸道疾病及斑块型寻常型银屑病具有潜在的应用价值。
产品描述
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
体外活性
AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells[1]. AZD0284 reduces polarization of TH17 into pathogenic TH17/1 cells. AZD0284 decreases frequency of single IL-17+cell as well as double positive TH17/1 cells. AZD0284 reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22 and IL-23R[1][2].
Cas No.
2101291-07-8
分子式
C21H18F6N2O5S
分子量
524.43
储存和溶解度
DMSO:99 mg/mL (188.77 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
