SR0987是SR1078 的类似物，是RORγt的激动剂，其EC50=800 nM。它可上调IL17 的表达，并且抑制PD-1 的表达。
产品描述
SR0987 is a RORγt agonist,
体外活性
SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production.SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM.
Cas No.
303126-97-8
分子式
C16H10ClF6NO2
分子量
397.7
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
