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SPDP-C6-NHS ester
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SPDP-C6-NHS ester图片
CAS NO:158913-22-5
包装与价格:
包装价格(元)
5mg询价
10mg询价

SPDP-C6-NHSester是一种PROTAClinker,属于alkyl/ether类。可用于合成PROTAC分子。
Cas No.158913-22-5
别名琥珀酰亚胺基-6-[3-(2-吡啶基二硫基)丙酰胺基]己酸
Canonical SMILESO=C(CCCCCNC(CCSSC1=NC=CC=C1)=O)ON2C(CCC2=O)=O
分子式C18H23N3O5S2
分子量425.52
溶解度DMSO: 100 mg/mL (235.01 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SPDP-C6-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 
 
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