Benzthiazide 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂，他对 CA9，CA2 和 CA1 的Ki分别为 8.0，8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。

Benzthiazide is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

91-33-8

C15H14ClN3O4S3

431.94

Dihydrex;Aquatag;Lemazide;苄噻嗪

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years