Venlafaxine HCl(Wy 45030 HCl)

Molecular Weight (MW)	313.86
Formula	C17H27NO2·HCl
CAS No.	99300-78-4
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 55 mg/mL (176.8 mM)
Water: 55 mg/mL (176.8 mM)
Ethanol: 55 mg/mL (176.8 mM)
Other info	Chemical Name: 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol hydrochloride InChi Key: QYRYFNHXARDNFZ-UHFFFAOYSA-N InChi Code: InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H SMILES Code: OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1.[H]Cl
Synonyms	Wy-45030; Trade names: Effexor, Effexor XR, Lanvexin, Viepax and Trevilor. Wy45030; Wy 45030;

Molecular Weight (MW)

313.86

Formula

C17H27NO2·HCl

CAS No.

99300-78-4

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 55 mg/mL (176.8 mM)

Water: 55 mg/mL (176.8 mM)

Ethanol: 55 mg/mL (176.8 mM)

Other info

Chemical Name: 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol hydrochloride

InChi Key: QYRYFNHXARDNFZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

SMILES Code: OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1.[H]Cl

Synonyms

Wy-45030; Trade names: Effexor, Effexor XR, Lanvexin, Viepax and Trevilor. Wy45030; Wy 45030;

In Vitro	In vitro activity: Venlafaxine has a low potential to inhibit the metabolism of substrates for CYP2D6 such as imipramine and desipramine compared with several of the most widely used SSRIs, as well as the metabolism of substrates for several of the other major human hepatic P450s. Venlafaxine inhibits binding to the human norepinephrine (NE) and serotonin (5-HT) transporters with K(i) values of 2480 nM and 82 nM, respectively, and with a K(i) ratio of 30. Venlafaxine has ED(50) values of 5.9 mg/kg and 94 mg/kg for blocking p-chloramphetamine- and 6-hydroxydopamine-induced monoamine depletion, respectively.
In Vivo	Venlafaxine induces a dose-dependent antinociceptive effect following i.p. administration with an ED50 of 46.7 mg/kg in mice. Venlafaxine-induced antinociception is significantly inhibited by naloxone, nor-BNI and naltrindole but not by beta-FNA or naloxonazine, implying involvement of kappa1- and delta-opioid mechanisms in mice. Venlafaxine reverses hyperalgesia in rats with a fully developed neuropathic lesion. Venlafaxine also appears to have a mild non-specific analgesic effect that increased paw withdrawal latency (PWL) in the sham limb.
Animal model	Mice
Formulation & Dosage	46.7 mg/kg; i.p.
References	Br J Clin Pharmacol. 1997 Jun;43(6):619-26; Pain. 1996 Nov;68(1):151-5.

In Vitro

In vitro activity: Venlafaxine has a low potential to inhibit the metabolism of substrates for CYP2D6 such as imipramine and desipramine compared with several of the most widely used SSRIs, as well as the metabolism of substrates for several of the other major human hepatic P450s. Venlafaxine inhibits binding to the human norepinephrine (NE) and serotonin (5-HT) transporters with K(i) values of 2480 nM and 82 nM, respectively, and with a K(i) ratio of 30. Venlafaxine has ED(50) values of 5.9 mg/kg and 94 mg/kg for blocking p-chloramphetamine- and 6-hydroxydopamine-induced monoamine depletion, respectively.

In Vivo

Venlafaxine induces a dose-dependent antinociceptive effect following i.p. administration with an ED50 of 46.7 mg/kg in mice. Venlafaxine-induced antinociception is significantly inhibited by naloxone, nor-BNI and naltrindole but not by beta-FNA or naloxonazine, implying involvement of kappa1- and delta-opioid mechanisms in mice. Venlafaxine reverses hyperalgesia in rats with a fully developed neuropathic lesion. Venlafaxine also appears to have a mild non-specific analgesic effect that increased paw withdrawal latency (PWL) in the sham limb.

Animal model

Mice

Formulation & Dosage

46.7 mg/kg; i.p.

References

Br J Clin Pharmacol. 1997 Jun;43(6):619-26; Pain. 1996 Nov;68(1):151-5.

CAS NO:	99300-78-4
规格:	≥98%

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