XEN723 是新型的硬脂酰辅酶 A 去饱和酶的噻唑基咪唑烷酮抑制剂，能够抑制小鼠和 HepG2 细胞的活性，它们的IC50值分别为 45 和 524 nM。
产品描述
XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
体外活性
XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively). XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit.
Cas No.
1072803-08-7
分子式
C21H20FN5O2S
分子量
425.48
储存和溶解度
DMSO:100 mg/mL (235.03 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
