Etilefrine is a sympathomimetic amine.¹It induces vasoconstriction in isolated perfused rat tail artery segments in a concentration-dependent manner. Etilefrine (45 µg/kg, i.v.) inhibits anesthesia-induced decreases in mean arterial pressure and cardiac output in dogs.²Formulations containing etilefrine have been used in the treatment of orthostatic hypotension.

1.Frost, B.R., Frewin, D.B., and Gerke, D.C.The effects of etilefrine on blood vessels in the rat tailJ. Pharm. Pharmacol.29(5)272-275(1977) 2.Tarnow, J., BrÜckner, J.B., Eberlein, H.J., et al.Haemodynamic responses to ethylphenylephrine (Effortil) during halothane-induced myocardial depression in the dogActa Anaesthesiol. Scand.17(3)184-189(1973)