NDI-091143 是高亲和力人 ATP 柠檬酸裂解酶抑制剂，其IC50为 2.1 nM (ADP-Glo分析)，Ki为 7.0 nM，Kd为 2.2 nM。它能够稳定柠檬酸盐域中的大构象变化，间接抑制柠檬酸的结合和识别，进而抑制ACLY催化变构反应。
产品描述
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding via an unexpected mechanism of inhibition.
Cas No.
2375840-87-0
分子式
C20H14ClF2NO5S
分子量
453.84
储存和溶解度
DMSO:91 mg/mL (200.51 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
