STF31 是一种葡萄糖转运蛋白 1 的选择性抑制剂，IC50为 1 μM。
产品描述
STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.
体外活性
STF-31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1. STF-31 significantly inhibits lactate production and extracellular acidification in VHL-deficient cells by about 60%, and decreases glycolysis by decreasing glucose transport. [1] In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT. [2] STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. [3]
体内活性
In mice with VHL-deficient RCC xenografts, a more soluble analog of STF-31 (11.6 mg/kg, i.p.) markedly delays tumor growth. [1]
Cas No.
724741-75-7
分子式
C23H25N3O3S
分子量
423.53
储存和溶解度
Ethanol:25 mg/mL (59.03 mM)
DMSO:42.4 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
