GT 949 是氨基酸转运蛋白 2 (EAAT2) 的选择性兴奋性正变构调节剂 (EC50：0.26 nM)。
产品描述
GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).
体外活性
GT 949 displays selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3. GT 949 improves glutamate transport (EC50 = 0.26 nM) and increases glutamate transport in a non-competitive manner with an increase in Vmax of about 47% in EAAT2-transfected cells[1].
Cas No.
460330-27-2
分子式
C30H37N7O2
分子量
527.66
储存和溶解度
DMSO:45mg/mL (85.3mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
