CD2665 是一种具有口服活性的视黄酸受体 (RAR) 拮抗剂。对于 RARγ 和 RARβ，Kis 为 110 nM 和 306 nM。
产品描述
CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
体外活性
In 3T3 cells, CD2665 (100 nM) abrogates the antiproliferative effects of ATRA, CD271 (adapalene, a RAR-β,γ agonist), and CD2043 (RAR-α,β,γ pan-agonist) returning cell numbers and percent LFCS to control level[1].
体内活性
In mice submitted to 10 months of ethanol consumption, CD2665 (0.6 mg/kg; s.c.) decreases brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels[2].
Cas No.
170355-78-9
分子式
C31H34O5
分子量
486.6
储存和溶解度
DMSO:22.5mg/mL (46.2mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
