| CAS NO: | 1265911-55-4 |
| 包装: | 1mg |
| 市场价: | 6426元 |
| Cas No. | 1265911-55-4 |
| 别名 | 替卡格雷 d7 |
| Canonical SMILES | FC(C(F)=C1)=CC=C1[C@@H]2C[C@H]2NC3=C4C(N([C@@H]5C[C@H](OCCO)[C@@H](O)[C@H]5O)N=N4)=NC(SC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=N3 |
| 分子式 | C23H21D7F2N6O4S |
| 分子量 | 529.6 |
| 溶解度 | DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 15 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ticagrelor-d7is intended for use as an internal standard for the quantification of ticagrelor by GC- or LC-MS. Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12receptor (Ki= 14 nM; IC50= 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.1,2It functions by directly changing the conformation of the P2Y12receptor to inhibit ADP binding.3Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome. 1.Zech, G., Hessler, G., Evers, A., et al.Identification of high-affinity P2Y12 antagonists based on a phenylpyrazole glutamic acid piperazine backboneJ. Med. Chem.55(20)8615-8629(2012) 2.Michelson, A.D.Advances in antiplatelet therapyHematology Am. Soc. Hematol. Educ. Program2011(1)62-69(2011) 3.Wallentin, L.P2Y12 inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical useEur. Heart J.30(16)1964-1977(2009) |
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