An internal standard for the quantification of doxazosin
| Cas No. | 1219803-95-8 |
| 别名 | 甲磺酸多沙唑嗪杂质 |
| Canonical SMILES | COC1=C(OC)C=C(C(N)=NC(N2C([2H])([2H])C([2H])([2H])N(C(C3COC(C=CC=C4)=C4O3)=O)C([2H])([2H])C2([2H])[2H])=N5)C5=C1.Cl |
| 分子式 | C23H17D8N5O5.HCl |
| 分子量 | 496 |
| 溶解度 | Acetonitrile:Methanol (1:1): soluble,DMSO: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Doxazosin-d8is intended for use as an internal standard for the quantification of doxazosin by GC- or LC-MS. Doxazosin is a non-selective antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.16, 1, and 3.98 nM for α1A-, α1B-, and α1D-ARs, respectively).1It inhibits norepinephrine-induced contractions in isolated rat aortic rings and human prostate strips with pA2values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2= 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension. 1.Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al.Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studiesBr. J. Pharmacol.118(4)871-878(1996) |
