LCZ696 是由 Valsartan (an ARB) 和 Sacubitril (AHU377) 组成，摩尔比为 1:1，是一种首创的，口服有效的血管紧张素受体-脑啡肽酶 (ARN) 双抑制剂，用于研究高血压和心力衰竭。它可通过抑制炎症、氧化应激和细胞凋亡来改善糖尿性心肌病。
产品描述
LCZ696 is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.
体外活性
LCZ696 is a single molecule that is comprised of molecular moieties of valsartan, an ARB, and AHU377, a neprilysin inhibitor (1:1 ratio)[1].
Cas No.
936623-90-4
分子式
C96H126N12Na6O21
分子量
1922.066
别名
Sacubitril mixture with Valsartan;沙库必曲/缬沙坦;Sacubitril;Valsartan;LCZ696
储存和溶解度
Ethanol:9 mg/mL (9.82 mM),warmed
H2O:92 mg/mL (100.4 mM)
DMSO:28 mg/mL (30.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
