Bay K 8644是一种二氢吡啶化合物，是一种选择性的 L 型 Ca2+ 通道激活剂，IC50 为 17.3 nM。它通过增加通道的开放时间来增加通过肌膜 Ca2+通道的 Ca2+流入。

Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel[2]

Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.[3]

71145-03-4

C16H15F3N2O4

356.3

SQ 28,873;(±)-BAY-K-8644

Ethanol:35.6 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years