CJ-13,610 hydrochloride 是一种具有口服活性的非氧化还原型 5-LOX 抑制剂，可用于预防 LTs 不良病理生理效应的研究。

CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological effects of LTs.

In intact human polymorphonuclear leukocytes (PMNL), challenged with the Ca(2+)-ionophore A23187, CJ-13,610 hydrochloride potently suppressed 5-LOX product formation with an IC50 of 70 nM. In transfected HeLa cells, CJ-13,610 hydrochloride only slightly discriminated between phosphorylatable wild-type 5-LOX and a 5-LOX mutant that lacks phosphorylation sites[2].

179420-27-0

C22H24ClN3O2S

429.96

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years