Pomalidomide-PEG3-C2-NH2TFA是一种合成的E3连接酶配体-linker偶联物，包含基于Pomalidomide的cereblon配体和3个单元PEG的linker。
| Cas No. | 2414913-97-4 |
| 别名 | 沙利度胺-NH-PEG3-NH2TFA,Cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA |
| Canonical SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCN)=O.OC(C(F)(F)F)=O |
| 分子式 | C23H29F3N4O9 |
| 分子量 | 562.49 |
| 溶解度 | DMSO: 100 mg/mL (177.78 mM); Ethanol: 100 mg/mL (177.78 mM); Water: 16.67 mg/mL (29.64 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. [1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. |
