Pomalidomide-C7-COOH是一种合成的E3连接酶配体-linker偶联物，是PROTACBCL-XL降解剂合成的中间体。
| Cas No. | 2225940-51-0 |
| 别名 | 泊马度胺4'-烷基C7-酸 |
| Canonical SMILES | O=C(O)CCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O |
| 分子式 | C21H25N3O6 |
| 分子量 | 415.44 |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Pomalidomide-C7-COOH is a synthesized E3 ligase cereblon ligand-linker conjugate. Pomalidomide-C7-COOH is an intermediate for the synthesis of PROTAC BCL-XL degraders[1]. [1]. Zhang X, et, al. Discovery of PROTAC BCL-X L degraders as potent anticancer agents with low on-target platelet toxicity. Eur J Med Chem. 2020 Apr 15; 192: 112186. |
