Dexrazoxane hydrochloride (ICRF-187 hydrochloride) 是一种心脏保护剂。
| Cas No. | 1263283-43-7 |
| Canonical SMILES | C[C@@H](CN2CC(NC(C2)=O)=O)N(CC(N1)=O)CC1=O.Cl |
| 分子式 | C11H16N4O4.HCl |
| 分子量 | 304.73 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway. Lebrecht et al (2007) Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. Br.J.Pharmacol 151 771 PMID:17519947 |Spallarossa et al (2010) Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexraz. J.Pharmacol.Exp.Ther. 332 87 PMID:19841470 |Classen et al (2003) Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc.Natl.Acad.Sci. 100 10629 |
