Mildronate 是心血管保护药，能够竞争性的抑制BBOX1和OCTN2。作用于人重组 BBOX 的(IC50:34-62 μM)、人OCTN2 (EC50:21 μM)。它n能够诱导长链脂肪酸代谢从线粒体向过氧化物酶体的重定向。
产品描述
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
体外活性
Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively. [1]
Cas No.
76144-81-5
分子式
C6H14N2O2
分子量
146.19
别名
Kvaterin;Quaterin;Meldonium;米屈肼
储存和溶解度
DMSO:Insoluble
H2O:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
