GSK2256294A 是重组人、大鼠和小鼠 sEH 的有效特异性抑制剂，IC50 分别为 27 pM、61 pM 和 189 pM。

GSK2256294A is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively.

GSK2256294A displays potent cellular inhibition of sEH with an IC50 of 0.66 nM in an assay developed using a cell line transfected with the human sEH enzyme[1].

Mice receiving 10 days of cigarette smoke exposure concomitant with oral administration of GSK2256294A exhibits significant, dose-dependent reductions in pulmonary leukocytes and keratinocyte chemoattractant levels. Mice receiving oral administration of G

1142090-23-0

C21H24F3N7O

447.46

GSK 2256294

DMSO:45 mg/mL (100.57 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years