SMIP004 是一种 SKP2 E3 连接酶抑制剂。 SMIP004 是人前列腺癌细胞的癌细胞特异性凋亡诱导剂。
产品描述
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
体外活性
SMIP004 reduces the levels of positive cell cycle regulators upregulates cyclin-dependent kinase inhibitors. It also causes G1 arrest, inhibition of colony formation in soft agar, and cell death [2].
体内活性
In SCID mice, SMIP004 effectively inhibits the growth of prostate and breast cancer xenografts [2].
Cas No.
143360-00-3
分子式
C13H19NO
分子量
205.3
储存和溶解度
DMSO:100 mg/mL (487.09 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
