NSC697923 是一种有效的 UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) 抑制剂。NSC697923 通过促进 p53 野生型神经母细胞瘤细胞中 p53 的核输入而诱导神经母细胞瘤细胞死亡。NSC697923 通过激活 JNK 介导的凋亡途径诱导 p53 突变神经母细胞瘤细胞死亡。NSC697923 抑制 DNA 损伤和 NF-Κb 信号传导。具有抗肿瘤活性。

NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity.

NSC697923 (0-5 μM; 24 hours) shows cytotoxic effect on NB cell lines. NSC697923 (3 μM; 2 hours) can also induce apoptosis in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 induces apoptosis in p53 wild-type NB cell lines by promoting p53 nuclear translocation and activation[1].

NSC697923 (5 mg/kg; i.p.; daily for 10 days) suppresses NB tumor growth in SH-SY5Y and NGP xenografts[1].

343351-67-7

C11H9NO5S

267.26

2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

DMSO:180mg/mL (673.5mM),Need ultrasonic
Ethanol:6.7 mg/mL (25 mM)),with gentle warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years