PI3K-IN-2 是一种有效的，可渗透脑的mTOR/PI3K抑制剂，是一种mTORC1和mTORC2抑制剂。它能够抑制PI3Kα,PI3Kδ,PI3Kβ,PI3Kγ和mTOR，IC50分别为 33 nM，451 nM，661 nM，708 nM 和 89 nM。

PI3K-IN-2 is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.

1225037-39-7

C17H20F3N7O2

411.38

PI3K-IN-2;PQR309;5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years