Ilaprazole sodium是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。

Ilaprazole, a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.

172152-50-0

C19H17N4NaO2S

388.42

艾普拉唑钠;IY-81149 sodium

DMSO:71 mg/mL(182.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years