KRas inhibitor-9 是一种KRas抑制剂，阻止 GTP-KRas 的形成和 KRas 下游激活。它以中等的结合亲和力与 KRas G12D、KRas G12C 和 KRas Q61H 蛋白结合，选择性抑制具有 KRas 突变的 NSCLC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。

KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells

300809-71-6

C13H9ClN2S2

292.8

DUN09716

DMSO:230 mg/mL (785.49 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years