| CAS NO: | 394694-98-5 |
| 包装 | 价格(元) |
| 500μg | 询价 |
| 1mg | 询价 |
| Cas No. | 394694-98-5 |
| 别名 | 3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼 |
| Canonical SMILES | O=C(N/N=C/C1=CC=C([N+]([O-])=O)S1)C2=CC=CC(F)=C2 |
| 分子式 | C12H8FN3O3S |
| 分子量 | 293.27 |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70[1]. MB-10 (100 μM) is a potential attenuator of protein import into mitochondria[1].MB-10 inhibits the import of substrates that use the TIM23 import pathway[1].MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria[1]. Cell Viability Assay[1] Cell Line: A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains. [1]. Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442. |
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