AZ PFKFB3 67 是一种有效的选择性代谢激酶 PFKFB3 抑制剂，对 PFKFB3、PFKFB2 和 PFKFB1 的 IC50 分别为 11、159 和 1130 nM。
| Cas No. | 1704741-11-6 |
| Canonical SMILES | N#CC1=CN(CC2=C(C)ON=C2C)C3=C1C=C(OC4=CC=C(NC([C@H]5NCCC5)=O)C=C4)C=C3 |
| 分子式 | C26H25N5O3 |
| 分子量 | 455.51 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent and selective PFKFB3 inhibitor (IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively). Boyd et al (2015) Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 58 3611 PMID:25849762 |
