SPT Imidazopyridine 1 (compound 1) 是一种具有口服活性且有效的 SPT（丝氨酸棕榈酰转移酶）抑制剂，对 hSPT1 的 IC50 为 5.19 nM。
| Cas No. | 1933533-18-6 |
| Canonical SMILES | CCCCCCC(C1=CN2C=CN=C2C(C3=CC=C(C=C3)CC(O)=O)=C1)=O |
| 分子式 | C22H24N2O3 |
| 分子量 | 364.44 |
| 溶解度 | <36.44mg/ml in DMSO |
| 储存条件 | Store at 4°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats. Genin et al (2016) Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 59 5904 PMID:27213958 |
