Alendronic acid，一种双膦酸盐，是法呢基二磷酸合酶 (FDPS) 抑制剂。Alendronic acid 抑制破骨细胞介导的骨吸收。Alendronic acid 对绝经后骨质疏松症，恶性高钙血症和 Paget 病具有疗效。
| Cas No. | 66376-36-1 |
| 别名 | 阿仑膦酸 |
| Canonical SMILES | OC(P(O)(O)=O)(CCCN)P(O)(O)=O |
| 分子式 | C4H13NO7P2 |
| 分子量 | 249.1 |
| 溶解度 | Water: 8.33 mg/mL (33.44 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget's disease[1]. [1]. Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12(3). pii: E293.
[2]. Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone Miner Res. 2019 Jun;34(6):1025-1032. |
