| CAS NO: | 1807540-84-6 |
| 包装: | 100mg |
| 市场价: | 5850元 |
| Cas No. | 1807540-84-6 |
| Canonical SMILES | O=C(OC1=C(F)C(F)=CC(F)=C1F)CCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O |
| 分子式 | C24H28F4N2O9 |
| 分子量 | 564.48 |
| 溶解度 | DMSO: 100 mg/mL (177.15 mM) |
| 储存条件 | -20℃, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mal-amido-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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