LNT 1 (compound 1) 是一种瓣状内切酶 1 (FEN1) 抑制剂。 LNT 1 与 FEN1 的活性位点结合，部分通过 Mg2+ 离子的配位实现抑制。
| Cas No. | 824983-91-7 |
| Canonical SMILES | ON1C(N(C2=C(C1=O)SC=C2)CC3COC4=CC=CC=C4O3)=O |
| 分子式 | C15H12N2O5S |
| 分子量 | 332.33 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response. Exell et al (2016) Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 12 815 PMID:27526030 |Ward et al (2017) Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 12 e0179278 PMID:28628639 |
