Pomalidomide-amido-C1-Br

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2351106-38-0

Pomalidomide-amido-C1-Br 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker。Pomalidomide-amido-C1-Br 可通过 PROTAC 技术合成 B-Raf 降解剂 PROTAC B-Raf degrader 1 。PROTAC B-Raf degrader 1 具有抗肿瘤活性。

Cas No.	2351106-38-0
Canonical SMILES	O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CBr
分子式	C₁₅H₁₂BrN₃O₅
分子量	394.18
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 . PROTAC B-Raf degrader 1 has anti-cancer activity[1]. [1]. Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Jun;87:191-199.