Eact 是一种选择性和有效的 TMEM16A 激活剂，可直接激活感觉伤害感受器中的 TRPV1 通道，还会产生瘙痒、急性伤害感受和热过敏。
产品描述
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.
体外活性
Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner (EC50: 11.6 ± 2.5 μM). Eact induces both itch-and pain- related behaviours in a TRPV1-dependent manner. TMEM16A activator Eact activates both native and recombinant TRPV1 channels[1].
Cas No.
461000-66-8
分子式
C22H24N2O5S
分子量
428.5
储存和溶解度
DMSO:50 mg/mL (116.69 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
