Phenytoin是一种有效的电压门控钠离子通道阻滞剂，可减少小鼠乳腺肿瘤的生长和转移，具有抗癫痫活性。

Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.

57-41-0

C15H12N2O2

252.273

5,5-Diphenylhydantoin;Diphenylhydantoin;苯妥英

DMSO:47 mg/mL (186.3 mM)
Ethanol:11 mg/mL (43.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years