Elexacaftor 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR的加工和转运，增加细胞表面CFTR的数量。
产品描述
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
体外活性
Elexacaftor (VX-445) has the potential to treat cystic fibrosis and it also is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore Phe508del CFTR protein function. VX-445-Tezacaftor-VX-770 significantly improves Phe508del CFTR protein processing, trafficking, chloride transport. To a greater extent than any two of these agents in dual combination[2].
Cas No.
2216712-66-0
分子式
C26H34F3N7O4S
分子量
597.65
别名
VX-445
储存和溶解度
DMSO:125 mg/mL (209.15 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
